In Parallel to characterising the conversation involving conolidine and ACKR3, The 2 teams went a step additional. The researchers made a modified variant of conolidine — which they identified as “RTI-5152-12” — which completely binds to ACKR3 with a good increased affinity. Like LIH383, a patented compound previously designed by https://www.proleviate.com/post/conolidine-alkaloid-for-chronic-pain