Biotin-Thiamine-Responsive Basal Ganglia Disease is an extremely rare autosomal recessive neurometabolic disorder characterized by recurrent waxing and waning episodes of subacute encephalopathy and seizures. High dose biotin and thiamine administration has been shown to improve symptoms within days. and the symptoms may reappear rapidly if supplementation is discontinued. Here we pre... https://www.soiebiologique.com/