Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis. Arf controls Mdm2. which in turn regulates p53. but Arf and Mdm2 also have p53-independent functions that affect tumor development. https://www.spidertattooz.com/OPI-GelColor-Magnet-Tool-Mauvnetic-Poles-0-5-oz-p21159/